Genome sequence of Halobacterium species NRC-1
نویسندگان
چکیده
منابع مشابه
Genome sequence of Halobacterium species NRC-1.
We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36% of which are unrelated to any previously reported. Analysis of the genome se...
متن کاملUnderstanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence.
The genome of the halophilic archaeon Halobacterium sp. NRC-1 and predicted proteome have been analyzed by computational methods and reveal characteristics relevant to life in an extreme environment distinguished by hypersalinity and high solar radiation: (1) The proteome is highly acidic, with a median pI of 4.9 and mostly lacking basic proteins. This characteristic correlates with high surfac...
متن کاملPost-genomics of the model haloarchaeon Halobacterium sp. NRC-1
Halobacteriumsp. NRC-1 is an extremely halophilic archaeon that is easily cultured and genetically tractable. Since its genome sequence was completed in 2000, a combination of genetic, transcriptomic, proteomic, and bioinformatic approaches have provided insights into both its extremophilic lifestyle as well as fundamental cellular processes common to all life forms. Here, we review post-genomi...
متن کاملEvolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1.
We report the sequence of the Halobacterium salinarum strain R1 chromosome and its four megaplasmids. Our set of protein-coding genes is supported by extensive proteomic and sequence homology data. The structures of the plasmids, which show three large-scale duplications (adding up to 100 kb), were unequivocally confirmed by cosmid analysis. The chromosome of strain R1 is completely colinear an...
متن کاملPoorly-conserved ORFs in the genome of the archaeon Halobacterium sp. NRC-1 correspond to expressed proteins
Motivation: A large fraction of Open Reading Frames (ORFs) identified as “hypothetical” proteins correspond to either “conserved hypothetical” proteins, representing sequences homologous to ORFs of unknown function from other organisms or to hypothetical proteins lacking any significant sequence similarity to other ORFs in the databases. Elucidating the functions and 3D structures of such orpha...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.190337797